Bile duct cancer (cholangiocarcinoma)

Bile duct cancer (cholangiocarcinoma)

• About bile duct cancer
• Symptoms of bile duct cancer
• Causes of bile duct cancer
• Diagnosing bile duct cancer
• Treating bile duct cancer
• Preventing bile duct cancer

About bile duct cancer

Bile duct cancer (cholangiocarcinoma) is a rare but aggressive type of cancer.

The bile duct system, or ‘biliary’ system, is made up of a series of tubes that begin in the liver and end in the small intestine. Bile is a fluid the digestive system uses to help break down fats and digest foods.

Symptoms of bile duct cancer

In most cases, there are no signs of bile duct cancer until it reaches the later stages, when symptoms can include:

• jaundice – yellowing of the skin and the whites of the eyes, itchy skin, pale stools and dark-coloured urine 
• unintentional weight loss
• abdominal pain

Speak to your GP if you have signs of jaundice or are worried about other symptoms. While it is unlikely you have bile duct cancer, it is best to get it checked.

Read more about the symptoms of bile duct cancer

Why does bile duct cancer happen?

The exact cause of bile duct cancer is unknown. However, some things may increase your chances of developing the condition. The most common include being over 65 years old or having a rare chronic liver disease called primary sclerosing cholangitis (PSC).

Read more about the causes of bile duct cancer

Types of bile duct cancer

There are 2 main types of bile duct cancer, depending on where the cancer begins:

• cancer that starts in a part of the bile duct inside the liver is known as intrahepatic bile duct cancer
• cancer that starts in part of the bile duct outside the liver is known as extrahepatic bile duct cancer

Diagnosis

Cancer of the bile duct can be difficult to diagnose, so you may need several tests, including: 

• blood tests
• ultrasound scans
• computerised tomography (CT) scans
• magnetic resonance imaging (MRI) scans

For some of these tests, you may need to be injected with a special dye that highlights your bile ducts.

You may also need a biopsy. This involves removing a small sample of tissue so it can be studied under a microscope. However, in some cases, your surgeon may prefer to remove the suspected tumour based on the results of your scans alone.

Read more about diagnosing bile duct cancer

How is bile duct cancer treated?

Cancer of the bile duct can usually only be cured if cancerous cells haven’t spread. If this is the case, some or all of the bile duct may be removed.

Only a small proportion of bile duct cancer cases are diagnosed early enough to be suitable for surgery. This is because symptoms usually develop at a late stage.

Despite this, treatment such as chemotherapy can relieve the symptoms of bile duct cancer and improve the quality of life of people in the advanced stages of the condition.

Read more about treating bile duct cancer

Who is affected?

Most cases of bile duct cancer occur in people over the age of 65. The condition affects men and women almost equally.

Can bile duct cancer be prevented?

There are no guaranteed ways to avoid getting bile duct cancer, but you can reduce your chances of developing it.

The most effective ways of achieving this are reducing your alcohol intake, as cirrhosis is a risk factor, and trying to ensure that you don’t become infected with hepatitis B or hepatitis C.